Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p392 | Osteoporosis: treatment | ECTS2016

The effect of oral dabigatran etexilate on bone density, strength, and microstructure in female and male mice

Bo Brent Mikkel , Skovhus Thomsen Jesper , Bruel Annemarie

Pradaxa (dabigatran etexilate) is a new anticoagulant, which recently has been approved for clinical use. Dabigatran etexilate (DE) is a direct thrombin inhibitor, which in addition to its effect on blood clotting, may have an anabolic effect on bone. Recently, it has been reported that DE could significantly reduce bone resorption and enhance bone formation resulting in a significant and substantial increase in trabecular bone mass in mice.The aim of th...